Matt Kayem was born in 1991,  in the small town of Mityana, Uganda. He currently lives and works in Kampala.
Both his parents owned a bookstore right in the heart of the town and Michael was introduced to writing and drawing from an early age. He attended Budo Junior School for his primary education, a traditionally prestigious school and continued to Mengo Senior School for his secondary level. At Mengo Senior, he took on art as a subject right from senior one. After his secondary school, he joined Michelangelo College of Creative Arts, Kisubi. After three years at the art school, he attained a certificate and diploma in art and design in October 2015. Kayem applies his skills in painting, sculpture, installation, performance, graffiti and photography; he is also an art writer/critic whose work has been published in Start Journal, africanah.org, ContemporaryAnd and psp-culture.com.
In his work, the African wax print fabric (kitenge) appears to comment on contemporary African people, fake versions of the real ones, that have lost their original identity after colonialism. Fabric is considered by the artist the right media to represent this issue thanks to its contested origin and debatable relationship with the continent. Denim usually represents the western influence while bark-cloth is usually used to represent our traditional and original nature as Africans. “My work hints on decolonization of myself and my kind and also a possible conscious integration and adoption of cultures alien to the African”.

He has participated in a number of group shows which include “Ekifananyi kya Muteesa” at Makerere art gallery and at the Photo Museum in Antwerp(2017), Laba Arts Festival(2016), Kampala Biennale(2016,2018) and others. Kayem has had three solo shows; Pop.Rap.Hip(2016), Cool Afrika(2018) and Cool Afrika 2(2019). Matt has been part of AtWork workshop by Simon Njami(2018), several art writing workshops and a finalist at the Mukumbya-Musoke art prize(2018).